INMA CAPO PDF

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Background: Adequate vitamin D status in mothers during pregnancy may influence the health status of the child later in life. We assessed whether maternal circulating hydroxyvitamin D 25[OH]D concentrations in pregnancy are associated with risk of lower respiratory tract infections, wheezing, and asthma in the offspring. When the child was age 1 year, parents were asked if their child had a physician-confirmed history of lower respiratory tract infections or a history of wheezing.

The questions about wheezing were repeated annually thereafter. Asthma was defined as parental report of doctor diagnosis of asthma or receiving treatment at the age of years or wheezing since the age of 4 years. Results: The median maternal circulating 25 OH D concentration in pregnancy was After multivariable adjustment, there was a trend for an independent association between higher levels of maternal circulating 25 OH D levels in pregnancy and decreased odds of lower respiratory tract infections in offspring for cohort- and season-specific quartile Q4 vs.

We found no association between 25 OH D levels in pregnancy and risk of wheezing at age 1 year or 4 years, or asthma at age years. Conclusions: Higher maternal circulating 25 OH D concentrations in pregnancy were independently associated with lower risk of lower respiratory tract infections in offspring in the first year of life but not with wheezing or asthma in childhood.

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Abstract Background: Adequate vitamin D status in mothers during pregnancy may influence the health status of the child later in life. Similar articles Cord-blood hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma.

Camargo CA Jr, et al. Epub Dec PMID: Plasmacytoid dendritic cells during infancy are inversely associated with childhood respiratory tract infections and wheezing. Upham JW, et al. J Allergy Clin Immunol. Epub Sep 6. Associations of maternal circulating hydroxyvitamin D3 concentration with pregnancy and birth outcomes. Rodriguez A, et al. Epub Sep Vitamin D and atopy and asthma phenotypes in children.

Hollams EM. Curr Opin Allergy Clin Immunol. PMID: Review. Childhood asthma may be a consequence of vitamin D deficiency. Litonjua AA. Show more similar articles See all similar articles. Thorsteinsdottir F, et al.

Eur J Pediatr. Association between vitamin D status in early pregnancy and atopy in offspring in a vitamin D deplete cohort. Smith M, et al.

Ir J Med Sci. Epub Aug Early life vitamin D status and asthma and wheeze: a systematic review and meta-analysis. Shen SY, et al. BMC Pulm Med.

Saggese G, et al. Ital J Pediatr. Show more "Cited by" articles See all "Cited by" articles. Publication types Research Support, Non-U. Gov't Actions. Child Actions. Child, Preschool Actions. Cohort Studies Actions. Female Actions. Humans Actions. Pregnancy Actions. Substances Vitamin D Actions. Full-text links [x] Wolters Kluwer. Copy Download.

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