Liver involvement in systemic lupus erythematosus: incidence, clinical course and outcome of lupus hepatitis. Clin Exp Rheumatol. Apparent hepatic dysfunction in lupus erythematosus. The spectrum of liver disease in systemic lupus erythematosus.

Author:Zuluzil Fenrikinos
Language:English (Spanish)
Published (Last):20 April 2013
PDF File Size:16.59 Mb
ePub File Size:2.65 Mb
Price:Free* [*Free Regsitration Required]

Barreales, S. Igarzabal 1 , T. Casis, F. Alonso-Navas 1 and J. Services of Digestive Diseases and 1 Internal Medicine. Hospital 12 de Octubre. Madrid, Spain.

We report the case of a patient that developed hepatic hydrothorax as the first complication of liver cirrhosis. Due to the lack of response to diuretics, pleurodesis and TIPS, treatment with octreotide was started with resolution of hydrothorax. To the best of our knowledge, this is the third reported case of refractory hepatic hydrothorax with complete and sustained response to octreotide. Key words: Hepatic hydrothorax. Liver cirrhosis.

Refractory hepatic hydrothorax: successful treatment with octreotide. Rev Esp Enferm Dig ; Correspondencia: M. Servicio de Medicina de Aparato Digestivo. It is defined as pleural effusion greater than ml in patients with liver cirrhosis and portal hypertension without cardiopulmonary disease.

There are many pathophysiologic theories that try to explain the mechanism of hepatic hydrothorax. Currently, the most accepted mechanism, involves the passage of ascitic fluid from the peritoneal cavity into the pleural space through diaphragmatic defects It is usually associated with ascites but there are cases of isolated hydrothorax Initial treatment is similar to that of hydropic decompensation and it consists of fluid and sodium restriction and diuretics. Patients with hydrothorax refractory to pharmacological treatment can be managed with pleurodesis or transjugular intrahepatic portosystemic shunt TIPS , although liver transplantation is the definitive treatment Over the last few years, two cases of successful treatment of hepatic hydrothorax with octreotide have been reported.

This led us to treat our patient with this drug. A year-old woman, with a past medical history of cigarette smoking and active alcohol consumption of 70 grams per day. Premature menopause treated with estrogens for more than 20 years.

She was admitted to another hospital the previous month with right hydrothorax. She was diagnosed with hepatic hydrothorax with a liver biopsy that revealed early micromacronodular cirrhosis, with moderate activity and focal steatosis. Viral, metabolic and autoimmune test were negative for the aetiology of liver disease.

Cardiopulmonary disease, as well as infectious disease, tuberculosis and pleural or lung cancer were excluded as the cause of the pleural effusion. Due to the absence of response to fluid and sodium restriction and diuretics she was submitted to thoracentesis and chest tube insertion to alleviate symptoms. She was admitted to our hospital one month later with recurrent right hydrothorax.

Physical examination showed decreased breath sounds over the right inferior hemithorax. Blood cell count revealed leukocytosis of Other laboratory values were as follows: creatinine level 1. On admission, pleural fluid analysis met exudative criteria total protein 3. Tuberculosis was excluded by the determination of alcohol-acid resistant bacilli and gamma-interferon in pleural fluid and negative mantoux. Moreover, malignancy was ruled out by cytologic examination of pleural fluid and pleural biopsy.

Doppler ultrasound revealed signs of chronic liver disease without morphologic nor hemodynamic signs of portal hypertension, mild ascites and right pleural effusion.

On the basis of absence of response to fluid and sodium restriction and diuretics, a chest tube was placed to relieve symptoms, with drainage of cc of fluid per day. Pleural effusion was complicated by acute prerenal failure due to excessive fluid loss and hypoproteinemia with hypoalbuminemia. In an attempt to control pleural fluid formation, a minithoracotomy with talc pleurodesis was performed without success.

After pleurodesis failure, and with hemodynamic evidence of mild portal hypertension hepatic venous pressure gradient: 13 mmHg which suggested liver disease as the cause of hydrothorax, TIPS placement was considered. There was a transient days decrease in chest drainage volume.

TIPS dysfunction was ruled out by doppler ultrasound. The patient had a good response to treatment with progressive decrease in chest tube drainage, allowing chest tube removal without recurrence of pleural effusion. Before discharge, a single dose of 10 mg subcutaneous octreotide was administered. No recurrence of hydrothorax or ascites has occurred within six months of discharge with a 25 mg dose of aldactone daily. Its pathophysiology is unclear and it involves movement of ascitic fluid from the peritoneal cavity to the pleural space through micro- or macroscopic diaphragmatic defects Pleural effusion is usually a transudate.

In our case, the presence of pleural exudate with positive culture for coagulase-positive Staphylococcus aureus was interpreted as empyema secondary to previous procedures. Findings allowed the exclusion of tumoral and infectious diseases and the presence of signs of portal hypertension led to the diagnosis of cirrhosis as the cause of hydrothorax. The management of this complication is usually difficult, with few therapeutical options.

The only definitive treatment is liver transplantation 19,20 , and it must be always considered in these patients. Initial treatment is similar to that of ascites and consists of fluid and sodium restriction and diuretics 16, Refractory hepatic hydrothorax is defined as pleural effusion that persists despite adequate treatment with the highest tolerable dose of diuretics.

These are the most severely ill and difficult patients. Management is dependent on respiratory symptoms caused by hydrothorax 16 and consist of several therapeutic approaches: repeated thoracenteses, chest tube insertion, pleurodesis and TIPS.

Patients with severe dysnea often require chest tube placement, which is also used to treat iatrogenic or spontaneous infection of pleural effusion.

This procedure has many complications such as excessive protein, fluid and electrolyte depletion. Chest tube removal is often impossible due to high volume drainage. This has led many authors to contraindicate chest tube placement in these patients There are some reported cases of successful treatment with pleurodesis. Talc is administered during thoracoscopy, performed to repair diaphragmatic defects if detected. However, this treatment has a high morbimortality rate as it is an invasive technique and it is usually performed in severely debilitated patients 16, We considered this option for our patient due to the absence of response to previous treatments and with the objective of pleurodesis and detection of diaphragmatic defects, as well as to perform a close examination of the thoracic cavity, taking biopsy samples to definitely exclude malignancy.

The procedure was unsuccessful maintaining high chest tube drainage that did not allow chest tube removal. According to literature, TIPS is the most effective treatment for refractory hepatic hydrothorax and it is considered one of the indications for this technique 9,15, Apart from reducing hepatic venous pressure gradient, it improves renal function It has also been reported to facilitate chest tube removal 15, Although it is a safe, little-invasive and efficient procedure, it has two major inconveniences: frequent obstruction of the prosthesis and development of hepatic encephalopathy 9.

To prevent adverse outcomes after TIPS placement, patients should be carefully selected, avoiding those with hepatic encephalopathy or with Child C cirrhosis After pleurodesis failure and once excluded etiologies for hydrothorax other than liver disease, our patient underwent a hemodynamic study. Based on hemodynamic evidence of mild portal hypertension, TIPS was performed. There was an initial response after the procedure, with a decrease in chest drainage volume, that did not allow chest tube removal.

This response was transient as drainage volume subsequently increased despite normal function of the prosthesis, as assesses by doppler ultrasound. Besides, she developed hepatic encephalopathy that responded to conventional treatment. There are two reported cases of treatment of refractory hepatic hydrothorax with octreotide in patients without other invasive options because of poor condition.

Treatment with octreotide was justified as it has the same effect as TIPS in reducing portosystemic pressure gradient. This drug has few and minor side effects 15, Based on good response to octreotide treatment in these cases we considered this treatment for our patient.

In the reported cases, the effect was dose dependent since higher doses led to greater reduction of drainage volume. Our patient had progressive improvement, allowing chest tube removal after five days of treatment Fig. We decided to continue treatment for several days by subcutaneous administration before discharge. Hydrothorax has not recurred within six months of discharge. To the best of our knowledge, this is the third reported case of refractory hepatic hydrothorax with response to octreotide.

Contrary to the two previous case reports 15,20 , our patient had failed to all available treatment options, including pleurodesis and TIPS. It is possible that TIPS and octreotide had a summatory effect on the decrease of portal hypertension. Based on this favorable response to octreotide, we think that splanchnic vasoconstrictors should be considered in the treatment of serious complications such as refractory hepatic hydrothorax and ascites.

Hepatic hydrothorax. Ann Intern Med ; Hepatic hydrothorax pathogenesis, diagnosis and management. Am J Med ; Cause and management. Arch Intern Med ; Pathogenesis and treatment of hydrothorax complicating cirrhosis with ascites.

An Med Interna ; Transyugular intrahepatic portal systemic shunt for the management of symptomatic cirrhotic hydrothorax. Am J Gastroenterol ;


2016, NĂºmero 3

Hepatic hydrothorax in a patient with cirrhosis due primary sclerosing cholangitis. ISSN We present the case of a male patient 39 years old, with a history of primary sclerosing cholangitis for 9 years, complicated with portal hypertension and liver failure, he is in liver transplant program, followed up by Gastroenterology Service. He was admitted for respiratory failure, and massive left pleural effusion, with of features transudate and moderate ascites was noted aswell, we performes pleural and ascitic fluid drainage with concomitant infusion of intravenous albumin. The patient shows good tolerance and significant decrease in both pleural effusion and ascitic fluid. He was discharged in better condition and with increased doses of drugs for the treatment of ascites.


Como comorbilidades, presenta diabetes mellitus tipo 2 controlada. Se le encuentra un derrame pleural izquierdo figura 1. Algunos pacientes pueden tener ascitis leve, o hasta no detectable. Sin embargo, Xiol X.


Hepatic hydrothorax: case report and literature review. Rev Col Gastroenterol [online]. ISSN Hepatic hydrothorax is a rare complication that occurs in patients with liver cirrhosis.


Barreales, S. Igarzabal 1 , T. Casis, F. Alonso-Navas 1 and J. Services of Digestive Diseases and 1 Internal Medicine.

Related Articles