The Spanish Association of Pediatrics has as one of its main objectives the dissemination of rigorous and updated scientific information on the different areas of pediatrics. Annals of Pediatrics is the Body of Scientific Expression of the Association and is the vehicle through which members communicate. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two receding years. CiteScore measures average citations received per document published. Read more. SRJ is a prestige metric based on the idea that not all citations are the same.
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Herpes simplex encephalitis HSE is the most common cause of sporadic focal encephalitis worldwide. Acyclovir is the treatment of choice of HSE since the s. After the widespread use of acyclovir, HSE related mortality rate had reduced but resistant strains emerged. Acyclovir resistant HSV incidence was reported as about 0.
Herein, a year-old immunocompetent patient with HSV-1 encephalitis who was successfully treated with combined acyclovir and foscarnet therapy is described. In the case of deteriorating clinical condition under acyclovir treatment even if the absence of demonstration of increased CSF HSV viral load, the possibility of acyclovir resistant HSE and the addition of foscarnet to the acyclovir treatment might be considered. Keywords: Acyclovir; Child; Foscarnet; Herpes simplex encephalitis.
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Full-text links Cite Favorites. Abstract in English , Spanish. Similar articles Herpes simplex encephalitis : from virus to therapy. Rozenberg F, et al. Infect Disord Drug Targets. PMID: Review. Ogura H, et al. Rinsho Shinkeigaku. Epub Apr Acyclovir resistance in herpes simplex virus type I encephalitis: a case report. Bergmann M, et al. J Neurovirol.
Epub Oct Cakmak Celik F, et al. Mikrobiyol Bul. PMID: Turkish. Acyclovir resistance in herpes simplex encephalitis. Schulte EC, et al. Ann Neurol. PMID: Show more similar articles See all similar articles. Publication types Case Reports Actions. Child Actions. Drug Combinations Actions. Drug Resistance, Viral Actions.
Humans Actions. Male Actions. Remission Induction Actions. Treatment Failure Actions. Substances Antiviral Agents Actions. Foscarnet Actions. Acyclovir Actions. Full-text links [x] Sociedad Argentina de Pediatria. Copy Download.
Autoimmune encephalitis are a new category of inflammatory diseases of the central nervous system mediated by antibodies that attack neurotransmitter or protein receptors on the surface of neurons. The clinical syndromes are complex and are associated with manifestations that vary according to the type of antibody that is associated. The autoimmune response can start due to the presence of a tumour or viral infection, but in many case the cause remains unknown. In children and teenagers, the initial symptoms are usually different from those of adults and the disease is rarely associated with tumours. In this article, in addition to anti-NMDA encephalitis, the general aspects of autoimmune encephalitis are reviewed and the most common questions asked about treatment of these diseases are addressed. Title: Encefalitis autoinmunes. Las encefalitis autoinmunes constituyen una nueva categoria de enfermedades inflamatorias del sistema nervioso central mediadas por anticuerpos contra receptores de neurotransmisores o proteinas de la superficie neuronal.