CANALIZATION OF DEVELOPMENT BY MICRORNAS PDF

Here, we adopt an evolutionary developmental approach to study miRNA function by examining their expression throughout embryogenesis in both Caenorhabditis elegans and Drosophila melanogaster. We find that, in both species, miRNA transcriptomic shifts in a punctuated fashion during the mid-developmental transition, specifying two dominant modes of early and late expression profiles. Strikingly, late-expressed miRNAs are enriched for phylogenetic conservation and function by fine-tuning the expression of their targets, implicating a role in the canalization of cell types during differentiation. In contrast, early expressed miRNAs are inversely expressed with their targets suggesting strong target-inhibition. Taken together, our work exposes a bimodal role for miRNA function during animal development, involving late-expressed physiological roles and early expressed repressive roles.

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Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Read article at publisher's site DOI : Rendel JM. Gibson G , Wagner G. Flatt T. Rutherford SL , Lindquist S. Bartel DP. Prodromidou K , Matsas R. Front Cell Neurosci , , 18 Dec Sci Rep , 9 1 , 03 Sep Evol Dev , 21 5 , 03 Jul Bioessays , 41 4 :e, 01 Apr Review Free to read. Front Genet , , 12 Feb This data has been provided by curated databases and other sources that have cited the article.

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Share this article Share with email Share with twitter Share with linkedin Share with facebook. Canalization is a design principle wherein developmental pathways are stabilized to increase phenotypic reproducibility. We suggest that miRNA interactions with the network of protein-coding genes evolved to buffer stochastic perturbations and thereby confer robustness to developmental genetic programs. A model relating gene replicas and gene repression to phenotypic expression and variability. Rendel JM Proc.

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Canalization of Development by microRNAs

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Read article at publisher's site DOI : Rendel JM.

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PLoS Biol 8 6 : e This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Competing interests: The author has declared that no competing interests exist. It does not happen often that an entirely novel gene regulatory mechanism is revealed. The discovery of microRNAs miRNAs is one such finding that revolutionized our understanding of cellular events and of the intricacy of developmental processes [1] , [2]. With a very short recognition sequence determining its specificity for target mRNAs, each miRNA can potentially regulate hundreds of transcripts, though in many cases the physiological effects of miRNA targeting can be attributed to its binding to one major mRNA transcript.

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Canalization of development by microRNAs.

Animal development is an extremely robust process resulting in stereotyped outcomes. Canalization is a design principle wherein developmental pathways are stabilized to increase phenotypic reproducibility. We suggest that miRNA interactions with the network of protein-coding genes evolved to buffer stochastic perturbations and thereby confer robustness to developmental genetic programs. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable.

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Evolution under canalization and the dual roles of microRNAs—A hypothesis

Robustness is a fundamental property of biological systems. The type of robustness that ensures uniform phenotypic outcomes in the face of variation during an organism's development is called canalization. Here, we discuss the roles that microRNAs play in providing canalization to animal development, citing recent theoretical and experimental advances. MicroRNAs repress protein expression, and they do this in ways that create thresholds in expression and provide adaptation to regulatory networks. Numerous examples have now been described where the developmental impact of environmental variation is suppressed by individual microRNAs.

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