ANEMIE HEMOLYTIQUE AUTOIMMUNE PDF

Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed. A rare, autoimmune disorder in which various types of auto-antibodies are directed against red blood cells causing their survival to be shortened and resulting in hemolytic anemia. AIHA can be primary idiopathic , secondary to infection or associated with diseases such as B-cell lymphomas, other systemic or organ-specific autoimmune diseases, Hodgkin's disease, hepatitis or primary immunodeficiencies, or, in the case of drug-induced AIHA, caused by a reaction to drugs.

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We'd like to understand how you use our websites in order to improve them. Register your interest. Hemolytic anemia is not an exceptional situation in adults. The abrupt onset of hemolysis and the severity of anemia may sometimes be life-threatening and require admission to the intensive care unit.

Establishing the hemolytic mechanism of an anemia is rather easy, but finding its etiology can be quite difficult. The diagnosis of severe hemolytic anemia requires a rapid multiple-step procedure taking into account patient and family history, a careful analysis of the blood smear as well as the result of a direct antiglobulin test.

This is a preview of subscription content, log in to check access. A review. Biochimie — Michel M [Warm autoimmune hemolytic anemias and Evans syndrome in adults]. Rev Med Interne — Br J Haematol — Arch Pediatr — Lancet Cell — Blood — Hall SE, Rosse WF The use of monoclonal antibodies and flow cytometry in the diagnosis of paroxysmal nocturnal hemoglobinuria. Allen DW, Manning N Abnormal phospholipid metabolism in spur cell anemia: decreased fatty acid incorporation into phosphatidylethanolamine and increased incorporation into acylcarnitine in spur cell anemia erythrocytes.

J Clin Oncol — N Engl J Med — Curr Opin Hematol — Google Scholar. Am J Hematol — Immunohematology — Habibi, C. Guillaud, M. Valent P, Lechner K Diagnosis and treatment of autoimmune haemolytic anaemias in adults: a clinical review. Wien Klin Wochenschr — J Clin Pathol — Transfus Med — Rev Med Int — Salama A Drug-induced immune hemolytic anemia.

Expert Opin Drug Saf — Transfusion — South Med J — George JN Clinical practice. Thrombotic thrombocytopenic purpura. Fremeaux-Bacchi V, Fakhouri F, Garnier A, et al Genetics and outcome of atypical hemolytic uremic syndrome: a nationwide French series comparing children and adults. Clin J Am Soc Nephrol — Potasman I, Prokocimer M The added value of peripheral blood cell morphology in the diagnosis and management of infectious diseases—part 2: illustrative cases.

Postgrad Med J — Prokocimer M, Potasman I The added value of peripheral blood cell morphology in the diagnosis and management of infectious diseases—part 1: basic concepts.

Semin Hematol — Intensive Care Med — Report of 2 cases]. Ann Biol Clin Paris — Monzon C, Miles J Hemolytic anemia following a wasp sting. J Pediatr — Annu Rev Entomol — Philippe P [Autoimmune hemolytic anemia: diagnosis and management]. Presse Med — Michel M [Characteristics of warm autoimmune hemolytic anemia and Evans syndrome in adults]. Novaretti MC, Jens E, Pagliarini T, et al Comparison of conventional tube test technique and gel microcolumn assay for direct antiglobulin test: a large study.

J Clin Lab Anal — Hematology — Indian J Pathol Microbiol — Wang Z, Shi J, Zhou Y, Ruan C Detection of red blood cell-bound immunoglobulin G by flow cytometry and its application in the diagnosis of autoimmune hemolytic anemia.

Int J Hematol — Bain BJ Diagnosis from the blood smear. An X, Mohandas N Disorders of red cell membrane. Download references. Correspondence to M. Reprints and Permissions. Michel, M. Download citation. Received : 03 April Accepted : 25 June Published : 11 July Issue Date : September Search SpringerLink Search. Abstract Hemolytic anemia is not an exceptional situation in adults. Reid HA Cobra-bites. Michel Authors M.

Michel View author publications. You can also search for this author in PubMed Google Scholar. Rights and permissions Reprints and Permissions. About this article Cite this article Michel, M.

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Autoimmune hemolytic anemia is a rare condition in children which differs from the adult form. It is defined by immune-mediated destruction of red blood cells caused by autoantibodies. Characteristics of the autoantibodies are responsible for the various clinical entities. Classifications of autoimmune hemolytic anemia include warm autoimmune hemolytic anemia, cold autoimmune hemolytic anemia, and paroxysmal cold hemoglobinuria. For each classification, this review discusses the epidemiology, etiology, clinical presentation, laboratory evaluation, and treatment options. Previous Article Editorial Board. Journal page Archives Contents list.

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Auto-immune hemolytic anemia associated with IgA is uncommon. Case report. Direct antiglobin test was positive only for IgA class autoantibodies. He recovered with a high dose corticosteroid treatment. Corticosteroid treatment is most often successful. Moussalem, R. Sacy, N.

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